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Senior Researcher
Miori Tanaka

Main Research Topics

Development and evaluation of methods for measuring nutrients and bioactive substances in human milk
Elucidation of the mechanisms of preventive effect of functional food ingredients on lifestyle-related diseases

Career History

Oct. 2021 – Present Senior Researcher, The Nippon Foundation Human Milk Bank
Apr. 2019 – Sep. 2021Assistant Professor, Tokyo University of Agriculture
Apr. 2018 – Mar. 2019Research Fellowships for Young Scientists (DC2), Japan Society for the Promotion of Science
Sep. 2016 – Feb. 2019Part-time Teacher, Nihon University
Aug. 2016 – Mar. 2017Academic Assistant, Ochanomizu University

Education

Apr. 2016 – Mar. 2019Department of Food and Nutritional Sciences, Graduate School of Humanities and Sciences, Ochanomizu University (PhD)
Apr. 2014 – Mar. 2016Department of Food and Nutritional Science, Graduate School of Humanities and Sciences, Ochanomizu University (MS)
Apr. 2010 – Mar. 2014Department of Nutrition and Food Science, Faculty of Human Life and Environmental Sciences, Ochanomizu University (BS)

Qualifications

Registered Dietitian, Diet and Nutrition Teacher (first class), Hazardous Materials Engineer's Licenses (Class A)

Professional Membership

Japan Society of Nutrition and Food Science, Japanese Society for Breastfeeding Research, Japan Society of Perinatal and Neonatal Medicine, Japan Society for Neonatal Health and Development, Japan Pediatric Society, The Molecular Biology Society of Japan, Japanese Society for Medical Use of Functional Foods, Japanese Society for Food Factors

Papers

  • Tanaka M, Date M, Mizuno K: New latex agglutination assay for the determination of lactoferrin in human milk: Int Breastfeed J: 19(1): 74: 2024
  • Ito M, Tanaka M, Date M, Miura K, Mizuno K: Immunological factors and macronutrient content in human milk from women with subclinical mastitis: J Hum Lact: 41(1): pp 26-33: 2025
  • Takahashi H, Morimoto H, Tanaka M, Inoue H, Goto T, Kawada T, Uehara M, Takahashi N: Myricetin and myricitrin indirectly and directly increases uncoupling protein-1 mRNA expression in C3H10T1/2 beige adipocytes: Biochem Biophys Res Commun: 734: 150771: 2024
  • Ikebukuro S, Tanaka M, Kaneko M, Date M, Tanaka S, Wakabayashi H, Murase M, Ninomiya N, Kamiya T, Ogawa M, Shiojiri D, Shirato N, Sekiguchi Y, Sekizawa A, Nakatsuka M, Gatanaga H, Mizuno K: Induced lactation in a transgender woman: case report: Int Breastfeed J: 19(1): 66: 2024
  • Takahashi H, Morikawa M, Ozaki E, Numasaki M, Morimoto H, Tanaka M, Inoue H, Goto T, Kawada T, Eguchi F, Uehara M, Takahashi N: A modified system using macrophage-conditioned medium revealed that the indirect effects of anti-inflammatory food-derived compounds improve inflammation-induced suppression of UCP-1 mRNA expression in 10T1/2 adipocytes: Biosci Biotechnol Biochem: 88(6): pp 679-688: 2024
  • Ito M, Tanaka M, Date M, Nagao S, Miura K, Mizuno K: Microbiota in human breast milk: Noninfectious mastitis versus without mastitis: Pediatr Int: 65(1): e15677: 2023
  • Arakawa K, Inoue H, Ishigami A, Sato A, Takino Y, Tanaka M, Morimoto H, Takahashi N, Uehara M: Release of SMP30 in extracellular vesicles under conditions of ascorbic acid deficiency is involved with acute phase response in ODS rat: J Nutr Sci Vitaminol: 69(6): pp 420-427: 2023
  • Inoue H, Shimizu Y, Yoshikawa H, Arakawa K, Tanaka M, Morimoto H, Sato A, Takino Y, Ishigami A, Takahashi N, Uehara M: Resveratrol upregulates senescence marker protein 30 by activating AMPK/Sirt1-Foxo1 signals and attenuating H2O2-induced damage in FAO rat liver cells: J Nutr Sci Vitaminol: 69(5): pp 388-393: 2023
  • Tanaka M, Inoue H, Takahashi N, Uehara M: AMPK negatively regulates RANKL-induced osteoclast differentiation by controlling oxidative stress: Free Radic Biol Med: 205: pp 107-115: 2023
  • Miura K, Tanaka M, Date M, Ito M, Mizuno N, Mizuno K: Comparison of bacterial profiles in human milk from mothers of term and preterm infants: Int Breastfeed J: 18(1): 29: 2023
  • Tanaka M, Date M, Miura K, Ito M, Mizuno N, Mizuno K: Protein and immune component content of donor human milk in Japan: variation with gestational and postpartum age: Nutrients: 15(10): 2278: 2023
  • Tanaka M, Fujii S, Inoue H, Takahashi N, Ishimi Y, Uehara M: (S)-Equol is More Effective than (R)-Equol in Inhibiting Osteoclast Formation and Enhancing Osteoclast Apoptosis, and Reduces Estrogen Deficiency-Induced Bone Loss in Mice: J Nutr: 152(8): pp 1831-1842: 2022
  • Inoue H, Arakawa K, Tanaka M, Katsumata-Tsuboi R, Takahashi N, Uehara M: Upregulation and stabilization of senescence marker protein-30 by epigallocatechin gallate against tert-butyl hydroperoxide-induced liver injury in vitro and in vivo: J Clin Biochem Nutr: 68(1): pp 51-57: 2021
  • Inoue H, Hanawa N, Katsumata SI, Aizawa Y, Katsumata-Tsuboi R, Tanaka M, Takahashi N, Uehara M: Iron deficiency negatively regulates protein methylation via the downregulation of protein arginine methyltransferase: Heliyon: 6(10): e05059: 2020
  • Tanaka M, Sato A, Kishimoto Y, Mabashi-Asazuma H, Kondo K, Iida K: Gallic acid inhibits lipid accumulation via AMPK pathway and suppresses apoptosis and macrophage-mediated inflammation in hepatocytes: Nutrients: 12(5): 1479: 2020
  • Tanaka M, Sugama A, Sumi K, Shimizu K, Kishimoto Y, Kondo K, Iida K: Gallic acid regulates adipocyte hypertrophy and suppresses inflammatory gene expression induced by the paracrine interaction between adipocytes and macrophages in vitro and in vivo: Nutr Res: 73: pp 58-66: 2020
  • Iwashima T, Kudome Y, Kishimoto Y, Saita E, Tanaka M, Taguchi C, Hirakawa S, Mitani N, Kondo K, Iida K: Aronia berry extract inhibits TNF-α-induced vascular endothelial inflammation through the regulation of STAT3: Food Nutr Res: 63: 3361: 2019
  • Taguchi C, Kishimoto Y, Takeuchi I, Tanaka M, Iwashima T, Fukushima Y, Kondo K: Estimated dietary polyphenol intake and its seasonal variations among Japanese university students: J Nutr Sci Vitaminol: 65(2): pp 192-195: 2019
  • Tanaka M, Kishimoto Y, Sasaki M, Sato A, Kamiya T, Kondo K, Iida K: Terminalia bellirica (Gaertn.) Roxb. extract and gallic acid attenuate LPS-induced inflammation and oxidative stress via MAPK/NF-κB and Akt/AMPK/Nrf2 pathways: Oxid Med Cell Longev: 2018: 9364364: 2018
  • Taguchi C, Kishimoto Y, Fukushima Y, Saita E, Tanaka M, Takahashi Y, Masuda Y, Goda T, Kondo K: Dietary polyphenol intake estimated by 7-day dietary records among Japanese male workers: evaluation of the within- and between-individual variation: J Nutr Sci Vitaminol: 63(3): pp 180-185: 2017
  • Tanaka M, Kishimoto Y, Saita E, Suzuki-Sugihara N, Kamiya T, Taguchi C, Iida K, Kondo K: Terminalia bellirica extract inhibits low-density lipoprotein oxidation and macrophage inflammatory response in vitro: Antioxidants: 5(2): 20: 2016

Awards

Sep. 2024Excellent Presentation Award, 38th Annual Meeting of the Japanese Society for Breastfeeding Research
Dec. 2022Young Investigator Excellent Abstract Award, 22nd International Congress of Nutrition
Sep. 2022Excellent Presentation Award, 36th Annual Meeting of the Japanese Society for Breastfeeding Research
Dec. 2018Excellent Presentation Award, 16th Annual Meeting of Japanese Society for Medical Use of Functional Foods
Nov. 2018Food Science Scholarship, Ochanomizu University
Mar. 201818th International Symposium on Atherosclerosis Travel Grant
Nov. 2017Excellent Presentation Award, 24th Congress of the Japan Mibyou Association
Dec. 2016Excellent Presentation Award, 14th Annual Meeting of Japanese Society for Medical Use of Functional Foods
Nov. 2014Excellent Presentation Award, 21st Congress of the Japan Mibyou Association

Competitive Research Funds

Elucidation of the role of human milk oligosaccharides in human milk microbiota formation and the concentration regulatory mechanism, Grant-in-Aid for Early-Career Scientists, Japan Society for the Promotion of Science, Apr. 2024 – Mar. 2027

 

Elucidation of the regulatory mechanism of human milk oligosaccharides for the prevention of necrotizing enterocolitis in preterm infants, Kawano Masanori Memorial Public Interest Incorporated Foundation for Promotion of Pediatrics, Apr. 2024 – Mar. 2025

 

Development of novel dietary therapy for bone diseases: regulation of osteoclast differentiation and apoptosis in obesity, Grant-in-Aid for Early-Career Scientists, Japan Society for the Promotion of Science, Apr. 2021 – Mar. 2025

 

AMPK-mediated regulation of osteoclast differentiation by food factors, Grant for Young Scientists of Japan Society of Nutrition and Food Science, May. 2020 – Mar. 2021

 

Study of regulatory mechanisms of bone metabolism by equol enantiomers, Grant-in-Aid for Research Activity Start-up, Japan Society for the Promotion of Science, Aug. 2019 – Mar. 2021

 

Elucidation of the mechanism of preventive effect of gallic acid on hepatic inflammation, Grant-in-Aid for JSPS Fellows, Japan Society for the Promotion of Science, Apr. 2018 – Mar. 2019

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